John Murdoch (Rufus Sewell) wakes in a hotel bathtub with no memory of who he is or how he got there, but there’s a body on the floor with bloody spirals carved into the flesh and a voice on the phone that tells him to flee. Soon Murdoch is on the run, wanted by the police, a woman who claims to be his wife and a group of mysterious pale men who seem to control everyone and everything in the city... except him.